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Prof. Tariq Mansoor is presently serving as the Vice-Chancellor, Aligarh Muslim University, Aligarh. Previously he has also served as Principal, J.N. Medical College, Chief Medical Superintendent, J.N. Medical College Hospital and Chairman, Department of Surgery. He is also the member of Medical Council of India since March 2015 for a period of four years. He is product of the first batch of prestigious Our Lady of Fatima Higher Secondary School, Aligarh. During his school days he has served as House Captain as well as School Captain. He did his MBBS and MS in General Surgery from Jawaharlal Nehru Medical College, AMU, Aligarh. A surgeon by profession with special interest in Breast and Thyroid Diseases, Prof. Tariq Mansoor has 33 years of Teaching and 35 years of Clinical experience. He has 90 publications to his credit and has guided 49 Postgraduate Medical Students for their Thesis as Supervisor / Co-Supervisor

High level of Vit D may lower cancer risk

High level of Vit D may lower cancer risk

Washington : High levels of vitamin D may be linked to a lower risk of developing cancer, including liver cancer, revealed a new study.

The study, conducted by a team of international researchers in Japan, stated that the findings support the theory that vitamin D might help protect against some cancers.

Vitamin D is made by the skin in response to sunlight. It helps to maintain calcium levels in the body to keep bones, teeth, and muscles healthy. While the benefits of vitamin D on bone diseases are well known, there is growing evidence that Vitamin D may benefit other chronic diseases, including some cancers.

But so far, most studies have been carried out in European or American populations, and evidence from Asian populations is limited.

As Vitamin D concentrations and metabolism can vary by ethnicity, it is important to find out whether similar effects would be seen in non-Caucasian populations.

So an international Japan-based research team set out to assess whether vitamin D was associated with the risk of total and site-specific cancer.

They analysed data from the Japan Public Health Center-based Prospective (JPHC) Study, involving 33,736 male and female participants aged between 40 to 69 years.

At the start of the study, participants provided detailed information on their medical history, diet, lifestyle, and blood samples were taken to measure vitamin D levels.

Vitamin D levels varied depending on the time of year the sample was taken, tend to be higher during the summer and autumn months than in the winter or spring.

After accounting for this seasonal variation, samples were split into four groups, ranging from the lowest to highest levels of vitamin D.

Participants were then monitored for an average of 16 years, during which time 3,301 new cases of cancer were recorded.

After adjusting for several known cancer risk factors, such as age, weight (BMI), physical activity levels, smoking, alcohol intake and dietary factors, the researchers found that a higher level of vitamin D was associated with a lower (around 20 percent) relative risk of overall cancer in both men and women.

Higher vitamin D levels were also associated with a lower (30-50 percent) relative risk of liver cancer, and the association was more evident in men than in women.

No association was found for lung or prostate cancer, and the authors note that none of the cancers examined showed an increased risk associated with higher vitamin D levels.

Findings were largely unchanged after accounting for additional dietary factors and after further analyses to test the strength of the results.

The researchers pointed to some study limitations, for example, numbers of organ-specific cancers were relatively small. And while they adjusted for several known risk factors, they cannot rule out the possibility that other unmeasured (confounding) factors may have influenced the results, making it difficult to draw firm conclusions about cause and effect.

Nevertheless, key strengths included the large sample size for overall cancer, a long follow-up period and a large number of blood samples analysed.

The authors said their findings support the theory that vitamin D may protect against the risk of cancer, but that there may be a ceiling effect, which may suggest that there are no additional benefits beyond a certain level of vitamin D.

“Further studies are needed to clarify the optimal concentrations [of vitamin D] for cancer prevention,” they concluded.

The findings from the study are published in The BMJ. (ANI)

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from The Siasat Daily

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