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Prof. Tariq Mansoor is presently serving as the Vice-Chancellor, Aligarh Muslim University, Aligarh. Previously he has also served as Principal, J.N. Medical College, Chief Medical Superintendent, J.N. Medical College Hospital and Chairman, Department of Surgery. He is also the member of Medical Council of India since March 2015 for a period of four years. He is product of the first batch of prestigious Our Lady of Fatima Higher Secondary School, Aligarh. During his school days he has served as House Captain as well as School Captain. He did his MBBS and MS in General Surgery from Jawaharlal Nehru Medical College, AMU, Aligarh. A surgeon by profession with special interest in Breast and Thyroid Diseases, Prof. Tariq Mansoor has 33 years of Teaching and 35 years of Clinical experience. He has 90 publications to his credit and has guided 49 Postgraduate Medical Students for their Thesis as Supervisor / Co-Supervisor

Blood-thinning drug could lower death risk post non-cardiac surgery

Blood-thinning drug could lower death risk post non-cardiac surgery

Washington: Dabigatran, a blood thinning drug, can significantly reduce the risk of death after non-cardiac surgery.

Researchers in Hamilton have discovered that the blood thinner lowers the risk of death, heart attack, stroke, and other heart or blood-vessel complications in patients who have a heart injury following major, non-cardiac surgery.

Every year, approximately eight million people world-wide develop a condition called myocardial injury after non-cardiac surgery (MINS), which refers to damage incurred to the tissue of the heart in response to the stress of surgery on the body.

The condition affects patients undergoing major procedures such as a hip or knee replacement, bowel resection, or abdominal aortic aneurysm repair, and can lead to severe complications including heart attack, stroke, blood clots, amputations, and death.

In the first randomized controlled trial to evaluate a treatment for MINS, Dr. P.J. Devereaux, scientific lead for perioperative research at the Population Health Research Institute (PHRI) of Hamilton Health Sciences and McMaster University and principal investigator for the MANAGE trial, found that patients who had MINS and received dabigatran twice daily were 28 per cent less likely to suffer a major vascular complication during an average of 16 months of follow-up.

“We now have an option for improving outcomes for a large population of people who have a heart injury after surgery each year,” says Dr. Devereaux.

The study enrolled 1,754 patients in 19 countries, 51 percent of whom were male, with an average age of 70 years. After an average follow-up of 16 months, 11 percent of patients treated with dabigatran experienced a MINS-related event, compared with 15 percent of patients who received a placebo. This translates to a 28 percent reduction in risk for patients receiving dabigatran.

An increased risk of bleeding is an expected complication of treatment with a blood-thinning medication; however, there was no significant difference between the two groups in terms of life-threatening, major, or critical organ bleeding. The MANAGE study builds on the discovery made by Dr. Devereaux and his colleagues last year which showed that a simple blood test could identify patients with MINS following surgery and alert clinicians to intervene before complications occurred.

“Patients with evidence of even mild damage to the heart after surgery are at high risk of adverse events in the long term,” says Dr. Salim Yusuf, chair of the MANAGE trial and executive director of PHRI. “It appears that this risk can be mitigated by antithrombotic therapy. Future studies can explore additional ways to reduce these risks.”

“This is an important issue that affects thousands of people around the world,” says Dr. Devereaux. “This discovery marks an important step in the journey to improve outcomes for patients who suffer MINS after surgery.”

The results of the MANAGE trial were presented at the American College of Cardiology’s 67th Annual Scientific Session. (ANI)

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from The Siasat Daily

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